Two hands for hotkeys

Heber Good tips in terms of absolute ergonomics and considering options available, but i think the suggestion has trade offs for certain macros. unless we plan to switch to keymouse 100 percent of the time we'll probably want to have habits that also work well with a regular keyboard and mouse or trackpad such as in the right hand the habit of for example copy paste cut close window quit etc using left handed keyboard combinations that rely only on the left hand even when the mouse is . So of course is one is very flexible one can adapt depending on the context and situation but if ones brain can handle so much it might be simplest to just consistently use the left handed only version of those key combinations so that they will always work in most every context. Also I get how physically there is less strain in typing one key per hand at a time where possible, but I wonder if mentally it may sometimes be easier to treat the action as something done by a single hand. Anyway good suggestions and I'm sure what I'm saying is pretty obvious anyway.